Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. Mol Vis 2000 6: 157–163.įontaine V, Mohand-Said S, Hanoteau N, Fuchs C, Pfizenmaier K, Eisel U.
Inhibition of neuroretinal cell death by insulin-like growth factor-1 and its analogs. Aggressive systematic treatment for central retinal artery occlusion. Graefes Arch Clin Exp Ophthalmol 1998 236: 766–774. Mechanism of the pathogenesis of glutamate neurotoxicity in retinal ischemia. Invest Ophthalmol Vis Sci 2001 42: 2695–2705.Īdachi K, Kashii S, Masai H, Ueda M, Morizane C, Kaneda K et al. Hypoglycemia induces general neuronal death, whereas hypoxia and glutamate transport blockade lead to selective retinal ganglion cell death in vitro. Molecular basis of glutamate toxicity in retinal ganglion cells. Rosenbaum PS, Gupta H, Savitz SI, Rosenbaum DM.
Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. Rosenbaum DM, Rosenbaum PS, Gupta A, Michaelson MD, Hall DH, Kessler JA. Neurodegenerative disorders and ischemic brain diseases. Mattson MP, Duan W, Pedersen WA, Culmsee C. Thus, XIAP-mediated gene therapy imparts both functional and structural protection to the retina after a transient ischemic episode. There were also significantly fewer TUNEL (TdT-dUTP terminal nick end labeling) positive cells in the INL of XIAP-treated retinas at 24 h post-ischemia. Similarly, there was no significant reduction in optic nerve axon numbers in XIAP-treated eyes. The number of cells in the inner nuclear layer (INL) and the thickness of the inner retina were significantly preserved in XIAP-treated eyes compared to GFP-treated eyes. Functional analysis revealed that XIAP-treated eyes retained larger b-wave amplitudes than GFP-treated eyes up to 4 weeks post-ischemia. We injected an adeno-associated viral vector expressing XIAP or GFP into rat eyes and 6 weeks later, rendered them ischemic by raising intraocular pressure. XIAP-mediated gene therapy has been shown to protect a number of neuronal types from apoptosis but has never been assessed in retinal neurons following ischemic-induced cell death. Recent studies have shown that most of the neuronal death that leads to loss of vision results from apoptosis. With Medvedev suffering a shoulder injury during the pre-match warm-up and needing lengthy treatment before he could start playing, it was no surprise Dimitrov won the first set after sprinting into a 5-0 lead.Retinal ischemia results in the loss of vision in a number of ocular diseases including acute glaucoma, diabetic retinopathy, hypertensive retinopathy and retinal vascular occlusion. "Those are things you dream of as a kid, so when it happens it feels good."ĭimitrov moved into the last four with a 6-3, 3-6, 6-3 win against Russia's Daniil Medvedev. "I was never top 30 before in my life, and now this year for the first time I have a "2" in front of my ranking.
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The 34-year-old's huge serve was on full display when he won the 's-Hertogenbosch title on grass last week and once again he used it to devastating effect against 2010 Queen's winner Querrey. Muller has won the first two ATP Tour titles of his career this year, helping him climb to a career-high ranking of 26, and he now has a seven-match winning streak on grass. Luxumbourg's Muller is through to his first Queen's semi-final after defeating 2010 champion Sam Querrey 6-4, 7-6 (7/5). "It is another match without losing serve, so that's extremely pleasing." I'm feeling great on the court," said Cilic, who is chasing his second ATP title this year.